KMID : 1161420110140111403
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Journal of Medicinal Food 2011 Volume.14 No. 11 p.1403 ~ p.1411
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Pistacia lentiscus Resin Regulates Intestinal Damage and Inflammation in Trinitrobenzene Sulfonic Acid?Induced Colitis
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Gioxari Aristea
Kaliora Andriana C. Papalois Apostolos Agrogiannis George Triantafillidis John K. Andrikopoulos Nikolaos K.
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Abstract
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Mastic (Pistacia lentiscus) of the Anacardiaceae family has exhibited anti-inflammatory and antioxidant properties in patients with Crohn's disease. This study was based on the hypothesis that mastic inhibits intestinal damage in inflammatory bowel disease, regulating inflammation and oxidative stress in intestinal epithelium. Four different dosages of P. lentiscus powder in the form of powder were administered orally to trinitrobenzene sulfonic acid?induced colitic rats. Eighty-four male Wistar rats were randomly assigned to seven groups: A, control; B, colitic; C?F, colitic rats daily supplemented with P. lentiscus powder at (C) 50?mg/kg, (D) 100?mg/kg, (E) 200?mg/kg, and (F) 300?mg/kg of body weight; and G, colitic rats treated daily with cortisone (25?¥ìg/kg of body weight). Colonic damage was assessed microscopically. The cytokines tumor necrosis factor-¥á, intercellular adhesion molecule-1 (ICAM-1), interleukin (IL)-6, IL-8, and IL-10 and malonaldehyde were measured in colonic specimens. Results were expressed as mean¡¾SE values. Histological amelioration of colitis (P¡Â.001) and significant differences in colonic indices occurred after 3 days of treatment. Daily administration of 100?mg of P. lentiscus powder/kg of body weight decreased all inflammatory cytokines (P¡Â.05), whereas 50?mg of P. lentiscus powder/kg of body weight and cortisone treatment reduced only ICAM-1 (P¡Â.05 and P¡Â.01, respectively). Malonaldehyde was significantly suppressed in all treated groups (P¡Â.01). IL-10 remained unchanged. Cytokines and malonaldehyde remained unaltered after 6 days of treatment. Thus P. lentiscus powder could possibly have a therapeutic role in Crohn's disease, regulating oxidant/antioxidant balance and modulating inflammation.
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KEYWORD
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Crohn's disease, immunomodulation, oxidative stress, Pistacia lentiscus, rats
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